1. In a zero order elimination process, which of the following is true?
A. The removal of drug is independent of drug concentration
B. Cl = Elimination rate/Cp
C. t1/2 = .7VD/Cl
D. All are true
B. Cl = Elimination rate/Cp
C. t1/2 = .7VD/Cl
D. All are true
2. For highly polar drugs (e.g. mannitol) what primarily determines elimination rate?
A. Excretion rate
B. Metabolism rate
C. Absorption rate
D. Distribution rate
E. All of the above
B. Metabolism rate
C. Absorption rate
D. Distribution rate
E. All of the above
3. Bioavailability is related to which of the following parameters, according to the equation F = 1 - E
A. Excretion
B. Elimination
C. Extraction Ratio
D. Enterohepatic Recycling
B. Elimination
C. Extraction Ratio
D. Enterohepatic Recycling
4. For the majority of drugs, which of the following equations correctly defines clearance?
A. Cl = Elimination rate/Cp
B. Cl = QxE
C. Cl = .7VD/t1/2
D. All are correct
B. Cl = QxE
C. Cl = .7VD/t1/2
D. All are correct
5. How much of a 10 mg dose of morphine reaches the systemic circulation given F = .24?
A. 24mg
B. 0.24 mg
C. 2.4 mg
D. 4.1 mg
B. 0.24 mg
C. 2.4 mg
D. 4.1 mg
6. Given that the VD = 230 L/70Kg and Cl = 60 L/hr/70 Kg for
morphine, approximately how much of a 10 mg IV dose remains after 8 hr,
given to a normal 70 Kg patient?
A. 5 mg
B. 2.5 mg
C. 1.25 mg
D. 625 mg
B. 2.5 mg
C. 1.25 mg
D. 625 mg
7. Given F = .24, what is the overall hepatic clearance of
morphine if the above patient has portal hypertension such that their
hepatic blood flow is reduced by ½? Assume the clearance value given in
the previous question is entirely hepatic clearance.
A. 30 L/hr/70 Kg
B. 60 L/hr/70 Kg
C. 120 L/hr/70 Kg
D. 250 L/hr/70 Kg
B. 60 L/hr/70 Kg
C. 120 L/hr/70 Kg
D. 250 L/hr/70 Kg
8. Which of the following enzymes could directly act on codeine?
A. Glucuronyl transferase
B. Sulfotransferase
C. Glutathione transferase
D. a & b
E. All of the above
B. Sulfotransferase
C. Glutathione transferase
D. a & b
E. All of the above
9. Which Cytochrome P450 isozyme does not participate appreciably in drug metabolism?
A. CYP1A2
B. CYP2C9
C. CYP3A4
D. CYP51
E. All are drug metabolizing isoforms
B. CYP2C9
C. CYP3A4
D. CYP51
E. All are drug metabolizing isoforms
10. Which of the following Cytochrome P450 isozymes is responsible for the bulk of phase I metabolism?
A. CYP1A2
B. CYP2C9
C. CYP2D6
D. CYP3A4
E. CYP51
B. CYP2C9
C. CYP2D6
D. CYP3A4
E. CYP51
11. Which of the following enzymes could metabolize ethanol?
A. Cytochrome P450
B. Alcohol Dehydrogenase
C. Glucuronyl Transferase
D. Sulfotransferase
E. All of the above
B. Alcohol Dehydrogenase
C. Glucuronyl Transferase
D. Sulfotransferase
E. All of the above
12. Which of the following are similarities between Cytochrome P450 and MAO?
A. Both add oxygen from O2 to substrates and also form water
B. Both carry out direct heteroatom oxidations
C. Both carry out oxidative deaminations
D. Both carry out N-dealkylations
E. All of the above
B. Both carry out direct heteroatom oxidations
C. Both carry out oxidative deaminations
D. Both carry out N-dealkylations
E. All of the above
13. What would be the preferred route of metabolism of succinyl choline?
A. Ester hydrolysis
B. N-oxidation
C. Glucuronide conjugation
D. a & b
E. All of the above
B. N-oxidation
C. Glucuronide conjugation
D. a & b
E. All of the above
14. Which of the following causes the smallest change in solubility?
A. Hydroxylation
B. Glucuronidation
C. Sulfation
D. Glutathione conjugation
B. Glucuronidation
C. Sulfation
D. Glutathione conjugation
15. Cigarette smoke causes an increase in levels of CYP1A
isozymes. Theophylline is primarily metabolized by the CYP1A system.
What would happen to theophylline clearance for an asthmatic patient in
hospital who could not smoke?
A. No change
B. Increase
C. Decrease
B. Increase
C. Decrease
Answer Key
1. A
2. A
3. C
4. D
5. C
6. C
7. A
8. D
9. D
10. E
11. E
12. C
13. C
14. A
15. C
1. A
2. A
3. C
4. D
5. C
6. C
7. A
8. D
9. D
10. E
11. E
12. C
13. C
14. A
15. C
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